THE BASIC PRINCIPLES OF SOK

The perform of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which performs a significant regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also encourage most